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KMID : 0363220110490070648
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Korean Journal of Dermatology
2011 Volume.49 No. 7 p.648 ~ p.651
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Congenital Melanocytic Nevus Showing an Unusual Clinical Manifestation
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Yang You-Jin
Kim Yoon-Hwan
Lee Joon
Kim Dong-Hoon
Kim Hee-Jung
Lee Ga-Young
Kim Won-Serk
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Abstract
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Completely neurotized melanocytic nevi are often clinically and histologically indistinguishable from neurofibromas. We report a 23-year-old female who presented with a dark brown plaque with an underlying soft blue subcutaneous nodule in the left infra-axillary area. The skin biopsy revealed markedly increased melanocytic proliferation and nests of nevus cells within dermo-epidermal junction and upper dermis. Circumscribed, non-encapsulated tumor of the dermis was composed of loosely-spaced spindle cells and wavy stroma. Spindle cells in the lower dermis showed staining for S-100, but failed to express glial fibrillary acidic protein and Leu-7. We present an interesting case because the lesion presented as a soft blue subcutaneous nodule suggested an underlying hemangioma or neurofibroma initially, but was shown to be a neurotized melanocytic nevus based on immunohistochemical examination.
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KEYWORD
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Congenital melanocytic nevus, Neurofibroma, Neurotized nevus
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